EdenteV2, Main, Exploration, bibRecord, 00AC09

Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Identifieur interne : 00AC09 ( Main/Exploration ); précédent : 00AC08; suivant : 00AC10

Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Auteurs : A. Fournet [France] ; A. Angelo Barrios ; V. Mu Oz ; R. Hocquemiller [France] ; F. Roblot [France] ; A. Cavé [France] ; P. Richomme [France] ; J. Bruneton [France]

Source :

Phytotherapy Research [ 0951-418X ] ; 1994-05.

RBID : ISTEX:2BC18EB9713CB6FD5A474A94A2FE4F8602C418A0

Descripteurs français

Wicri :
- topic : Bolivie.

English descriptors

KwdEn :
- Alkaloid, Alkaloidal, Amazonensis, Antiprotozoal activity, Balblc mice, Bolivia, Chimane, Chimane indians, Chimanine, Control mice, Crude alkaloidal extracts, Cruzi, Cutaneous, Cutaneous leishmaniasis, Epimastigote forms, First experiment, Fournet, Galipea, Galipea longiflora, Glucantime, Leishmania, Leishmania amazonensis, Leishmania species, Leishmaniasis, Lesion, Longiflora, Parasite, Plant material, Promastigote forms, Quinoline, Quinoline alkaloids, Rear footpad, Reference drug, Root bark, Trypanosoma, Trypanosoma cruzi, Uitro, Uitro activity.
Teeft :
- Alkaloid, Alkaloidal, Amazonensis, Antiprotozoal activity, Balblc mice, Bolivia, Chimane, Chimane indians, Chimanine, Control mice, Crude alkaloidal extracts, Cruzi, Cutaneous, Cutaneous leishmaniasis, Epimastigote forms, First experiment, Fournet, Galipea, Galipea longiflora, Glucantime, Leishmania, Leishmania amazonensis, Leishmania species, Leishmaniasis, Lesion, Longiflora, Parasite, Plant material, Promastigote forms, Quinoline, Quinoline alkaloids, Rear footpad, Reference drug, Root bark, Trypanosoma, Trypanosoma cruzi, Uitro, Uitro activity.

Abstract

The stem bark of Galipea longiflora is used by the Chimane Indians in Bolivia for the treatment of cutaneous leishmaniasis produced by Leishmania braziliensis. Petroleum ether and chloroform extracts of stem, root bark and leaves were found active in vitro against Leishmania ssp and Trypanosoma cruzi at 100 μg/mL. The activity guided fractionation of the extracts by chromatography afforded 12 active compounds identified as 2‐substituted quinoline alkaloids. BALB/c mice were infected with Leishmania amazonensis (strain PH8 or H‐142) and treated 24 h after infection with the major alkaloids from the crude alkaloidal extract; 2‐phenylquinoline and 2‐n‐pentylquinoline. 2‐phenylquinoline was as potent as Glucantime (Rhǒne‐Poulenc) against the strain H‐142, but less active than the reference drug against the virulent strain PH8 of L. amazonensis. 2‐n‐pentylquinoline did not exhibit any activity. Assays of single local treatments on the rear footpad infection, 2 weeks after the parasitic inoculation, indicated an effect for 2‐phenylquinoline by reducing the severity of lesion. However, this activity was found to be slightly lower than that obtained using Glucantime.

Url:

https://api.istex.fr/document/2BC18EB9713CB6FD5A474A94A2FE4F8602C418A0/fulltext/pdf

DOI: 10.1002/ptr.2650080312

Affiliations:

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Le document en format XML

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<term>Antiprotozoal activity</term>
<term>Balblc mice</term>
<term>Bolivia</term>
<term>Chimane</term>
<term>Chimane indians</term>
<term>Chimanine</term>
<term>Control mice</term>
<term>Crude alkaloidal extracts</term>
<term>Cruzi</term>
<term>Cutaneous</term>
<term>Cutaneous leishmaniasis</term>
<term>Epimastigote forms</term>
<term>First experiment</term>
<term>Fournet</term>
<term>Galipea</term>
<term>Galipea longiflora</term>
<term>Glucantime</term>
<term>Leishmania</term>
<term>Leishmania amazonensis</term>
<term>Leishmania species</term>
<term>Leishmaniasis</term>
<term>Lesion</term>
<term>Longiflora</term>
<term>Parasite</term>
<term>Plant material</term>
<term>Promastigote forms</term>
<term>Quinoline</term>
<term>Quinoline alkaloids</term>
<term>Rear footpad</term>
<term>Reference drug</term>
<term>Root bark</term>
<term>Trypanosoma</term>
<term>Trypanosoma cruzi</term>
<term>Uitro</term>
<term>Uitro activity</term>
</keywords>
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<term>Alkaloidal</term>
<term>Amazonensis</term>
<term>Antiprotozoal activity</term>
<term>Balblc mice</term>
<term>Bolivia</term>
<term>Chimane</term>
<term>Chimane indians</term>
<term>Chimanine</term>
<term>Control mice</term>
<term>Crude alkaloidal extracts</term>
<term>Cruzi</term>
<term>Cutaneous</term>
<term>Cutaneous leishmaniasis</term>
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<front><div type="abstract" xml:lang="en">The stem bark of Galipea longiflora is used by the Chimane Indians in Bolivia for the treatment of cutaneous leishmaniasis produced by Leishmania braziliensis. Petroleum ether and chloroform extracts of stem, root bark and leaves were found active in vitro against Leishmania ssp and Trypanosoma cruzi at 100 μg/mL. The activity guided fractionation of the extracts by chromatography afforded 12 active compounds identified as 2‐substituted quinoline alkaloids. BALB/c mice were infected with Leishmania amazonensis (strain PH8 or H‐142) and treated 24 h after infection with the major alkaloids from the crude alkaloidal extract; 2‐phenylquinoline and 2‐n‐pentylquinoline. 2‐phenylquinoline was as potent as Glucantime (Rhǒne‐Poulenc) against the strain H‐142, but less active than the reference drug against the virulent strain PH8 of L. amazonensis. 2‐n‐pentylquinoline did not exhibit any activity. Assays of single local treatments on the rear footpad infection, 2 weeks after the parasitic inoculation, indicated an effect for 2‐phenylquinoline by reducing the severity of lesion. However, this activity was found to be slightly lower than that obtained using Glucantime.</div>
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Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Antiprotozoal activity of quinoline alkaloids isolated from Galipea longiflora, a Bolivian plant used as a treatment for cutaneous leishmaniasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri